Apoptosis-associated speck-like protein containing a CARD (ASC) expression profiles in familial Mediterranean fever (FMF) patients with different MEFV mutation patterns
Makaleler > Tam Makale · 2012
Yazarlar: S NALBANTOGLU, Muhammed Bahattin TANYOLAÇ, Afig BERDELİ
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2012, cilt 42, ss 159-162
DOI: 10.3109/03009742.2012.699551
Özet
Objectives: The inflammasome complex and the inflammatory pathway have been implicated in the pathogenesis of the most common autoinflammatory disorder, familial Mediterranean fever (FMF). Pyrin, the protein product of the FMF gene MEFV, interacts with the inflammasome complex adaptor protein ASC/PYCARD (apoptosis-associated speck-like protein with a CARD). Pyrin and ASC can both function as either inducers or suppressors of the cellular inflammatory response. We aimed to characterize ASC-induced gene expression profiles in FMF patients with different MEFV mutation patterns.