In Vitro Activity of Linezolid against Mycobacterium tuberculosis Strains Isolated from Western Turkey
Articles > Article · 2009
Authors: Şafak ERMERTCAN, Mine HOŞGÖR LİMONCU, Bayrı ERAÇ, Hüseyin TAŞLI, Cengiz Cevusoglu, Hale Bozkurt
JAPANESE JOURNAL OF INFECTIOUS DISEASES, Journal Indexed in SCI Expanded, International, 2009, vol 62, pp 384-385
Summary
We investigated the linezolid susceptibility of Mycobacterium tuberculosis strains isolated from a tertiary care hospital in Izmir. A total of 67 M. tuberculosis strains (33 multidrug-resistant [MDR] and 34 non-MDR) were isolated and identified by the Tuberculosis Laboratory, Department of Microbiology and Clinical Microbiology, Faculty of Medicine, Ege University. The activity of linezolid was studied by the standard agar proportion method. For all of the strains, the MIC range was 0.06-1 mg/L, and the MIC50 and MIC90 values were 0.5 mg/L. No differences were observed between the MDR and non-MDR isolates. In general, linezolid was found to be effective for both the non-MDR and MDR M. tuberculosis strains.