Protective effect of Amifostine against cisplatin-induced motor neuropathy in rat
Makaleler > Tam Makale · 2003
Yazarlar: ŞUAYİB YALÇIN, GÜLAY NURLU, BÜLENT ORHAN, DİLARA ZEYBEK, SEVDA FATMA MÜFTÜOĞLU, Banu Pınar ŞARER YÜREKLİ, BA Yildirim, EREN ÇETİN
MEDICAL ONCOLOGY, SCI Expanded İndekslerine Giren Dergi, Uluslararası, 2003, cilt 20, ss 175-180
DOI: 10.1385/mo:20:2:175
Özet
Cisplatin (CDDP) is a potent anticancer drug. Neurotoxicity is one of the most important dose-limiting toxicity of CDDP. We investigated the role of amifostine in the protection against CDDP-induced neurotoxicity especially on the motor nerves. All experiments were conducted on female Wistar albino rats. Animals were randomly assigned to two groups, each including six rats. Group A received CDDP plus amifostine and Group B received CDDP only. Electroneurography (ENG) was carried out in the beginning and at the end of 7 wk; then, the rats were sacrificed and the sciatic nerve was removed for histopathological examination.