Multiple function of lncRNA MALAT1 in cancer occurrence and progression
Articles > Article ยท 2021
Authors: Faezeh Malakoti, Niloufar Targhazeh, Haniye Karimzadeh, Erfan Mohammadi, Milad Asadi, Zatollah Asemi, Forough Alemi
Chemical Biology & Drug Design, International, WoS, 2021, vol 101, pp 1113-1137
DOI: 10.1111/cbdd.14006
Summary
Long non-coding RNAs (lncRNAs) have received particular attention in the last decade due to its engaging in carcinogenesis and tumorigenesis. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a lncRNA that plays physiological and pathological roles in many aspects of genome function as well as biological processes involved in cell development, differentiation, proliferation, invasion, and migration. In this article, we will review the effects of lncRNA MALAT1 on the progression of six prevalent human cancers by focusing on MALAT1 ability to regulate post-transcriptional modification and signaling pathways.