Matrix metalloproteinase-2,-9, and-12 gene polymorphisms in generalized aggressive periodontitis
Articles > Article · 2007
Authors: Ali GÜRKAN, Gülnur EMİNGİL, Buket Han SAYGAN, FATMA GÜL ATİLLA, SERHAT ÇINARCIK, Timur KOESE, Afig BERDELİ
JOURNAL OF PERIODONTOLOGY, Journal Indexed in SCI Expanded, International, 2007, vol 78, pp 2338-2347
Summary
Background: Matrix metalloproteinases (MMPs) are involved in periodontal tissue remodeling and degradation. Polymorphisms in the promoter region of the MMP-2 and -9 genes and in the coding region of the MMP-12 gene could affect transcription and the function of these enzymes. The aim of the present study was to determine the association between the aforementioned MMP polymorphisms and generalized aggressive periodontitis (GAgP).