Synthesis, radiolabeling and in vitro evaluation of azathioprine loaded magnetic solid lipid nanoparticles
Makaleler > Tam Makale · 2023
Yazarlar: Gökce Türkkanı, Burcu Güngör, Oğuz Cetin, Çiğdem İÇHEDEF, Yasemin Parlak, F. Gül Gümüşer, B. Elvan Sayıt Bilgin, Serap TEKSÖZ
Journal of Radioanalytical and Nuclear Chemistry, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2023, cilt 332, ss 4695-4704
DOI: 10.1007/s10967-023-08975-5
Özet
In this study, it is aimed to design a smart drug delivery system for the diagnosis and treatment of cancer cells. Magnetic-solid lipid nanoparticles were synthesized as a drug delivery system and azathioprine (AZA) was loaded into this system. This newly created system was radiolabeled using technetium-99 m with a radiolabeling yield of 90.3%. Drug loading into the SLMNP was found as 86%. The biological behavior of 99mTc and radiolabeled magnetic solid lipid nanoparticles loaded with azathioprine (99mTc-AZA-SLMNP) was investigated in vitro and in vivo. Graphical abstract: [Figure not available: see fulltext.]