Thioguanine-Related Chronic Hepatotoxicity in a Child with Acute Myeloid Leukemia: A Case Report and Review
Articles > Article ยท 2015
Authors: Tuba Hilkay KARAPINAR, Yesim OYMAK, Cigdem ECEVIT, Funda YILMAZ BARBET, Miray KARAKOYUN, Yilmaz AY, Canan VERGIN
JOURNAL OF PEDIATRIC RESEARCH, Journal Indexed in SCI Expanded, International, 2015, vol 2, pp 102-104
DOI: 10.4274/jpr.69885
Summary
The association between 6-Thioguanine (6-TG) treatment and drug-induced liver injury has been reported since 1976. Recent reports have suggested that treatment of patients with 6-TG can lead to chronic hepatotoxicity and portal hypertension. Most of the cases reported to have 6-TG related hepatotoxicity had acute lymphoblastic leukemia or inflammatory bowel disease. In this case report, we discussed the diagnosis and approach in an acute myeloid leukemia patient who developed 6-TG related chronic hepatotoxicity.