Electrochemical investigation of biomolecular interactions between platinum derivatives and DNA by carbon nanotubes modified sensors
Articles > Article · 2010
Authors: Ece Yapasana, Ayfer CALİSKAN, Hakan KARADENİZ, Kadriye Arzum ERDEM GÜRSAN
MATERIALS SCIENCE AND ENGINEERING B-ADVANCED FUNCTIONAL SOLID-STATE MATERIALS, Journal Indexed in SCI Expanded, International, WoS, 2010, vol 169, pp 169-173
DOI: 10.1016/j.mseb.2009.10.024
Summary
The biomolecular interactions of platinum derivatives widely used as anticancer drugs: cis-diamminedichloroplatinum(II) and oxaliplatin with calf thymus double-stranded DNA were studied using differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS) in combination with single-walled carbon nanotubes modified graphite electrode (SWCNTs-GE) and unmodified graphite electrode (bare GE). The performance of these biomolecular interactions were explored at the electrode surface by monitoring the changes at guanine oxidation signal in terms of optimum interaction times by comparing the results of SWCNTs-GE with bare one. The features of these electrochemical sensors based on carbon nanotubes for monitoring of biomolecular interactions were discussed and compared with the earlier conventional ones. (C) 2009 Elsevier B.V. All rights reserved.