Liposomal Silver Nanoparticles Synthesized from Halopteris scoparia: A Sustainable Approach to Enhanced Antibacterial Activity
Makaleler > Tam Makale · 2026
Yazarlar: Ayşe Sinem Yıldırım, Kübra Bezir, İnci TÜNEY KIZILKAYA, MÜNEVVER MÜGE ÇAĞAL
Osmaniye Korkut Ata Üniversitesi Fen Bilimleri Enstitüsü Dergisi, Diğer Kurumların Hakemli Dergileri, Uluslararası, TR Dizin (Ulakbim), 2026, cilt 9, ss 475-490
Özet
The conventional physical and chemical methods for producing silver nanoparticles (AgNPs) often involve complex, costly, and environmentally detrimental processes. To address these challenges, researchers have explored a more sustainable approach known as green synthesis. This study aims to create AgNPs through the green synthesis method using extracts from Halopteris scoparia, with the goal of enhancing their antibacterial properties through liposomal encapsulation. In this context, we investigated the effects of temperature and pH on the synthesis of nanoparticles. The antimicrobial activities of both free AgNPs and liposomal AgNPs (L-AgNPs), produced under optimal conditions, were assessed against various bacterial strains. The smallest AgNPs derived from H. scoparia extracts measured 61.21 ± 1.537 nm, while the L-AgNPs were recorded at 84.32 ± 2.181 nm, with synthesis occurring at a pH of 9 and a temperature of 90 °C. The nanoliposomes demonstrated an encapsulation efficiency exceeding 87%, along with a nanometric particle size and narrow polydispersity. The minimum inhibitory concentration (MIC) values for free AgNPs and L-AgNPs were found to be 48.5 μg/μL and 24.5 μg/μL against E. coli, respectively. Similarly, the MIC values against S. aureus were 48.5 μg/μL for AgNPs and 24.5 μg/mL for L-AgNPs. All experimental results conclusively illustrate that the innovative liposomal system has significantly enhanced the antibacterial efficacy of AgNPs. These preliminary findings suggest that liposomes could serve as effective carriers for AgNPs in cosmetic and pharmaceutical applications.