Isolation and identification of a new saponin from Cephalaria aytachii
Makaleler > Tam Makale · 2016
Yazarlar: Peyker Kayce, Suheyla Kirmizigul
Natural Product Research, Uluslararası, Wos, 2016, cilt 31, ss 50-57
DOI: 10.1080/14786419.2016.1212029
Özet
A new hederagenin-type triterpenoid glycoside (1) named Aytachoside A, along with eight known triterpene glycosides, were isolated from the aerial parts of Cephalaria aytachii Gokturk and Sumbul (Dipsacaceae). The structures of compounds 1-9 were determined by spectroscopic (1D and 2D NMR, HRESIMS) and chemical examinations. The antimicrobial effect of compound 1 was found considerably active against Escherichia coli, Pseudomonas aeruginosa and especially Salmonella typhimurium microorganisms using the MIC method. Although compound 1 was found not to have a remarkable toxic effect at a concentration lower than 300 μg/mL, cytotoxic activity tests demonstrated that prosapogenin 1a exhibits a significant cytotoxic activity against HeLa cell lines using the MTT assay for the first time.