Iridium-Catalyzed Alkylation of Secondary Alcohols with Primary Alcohols: A Route to Access Branched Ketones and Alcohols
Makaleler > Tam Makale · 2020
Yazarlar: Sertac Genc, Süleyman GÜLCEMAL, Salih GÜNNAZ, Bekir Cetinkaya, Derya GÜLCEMAL
JOURNAL OF ORGANIC CHEMISTRY, SCI İndekslerine Giren Dergi, Uluslararası, Scopus, 2020, cilt 85, ss 9139-9152
Özet
Under borrowing hydrogen conditions, NHC–iridium(I) catalyzed the direct or one-pot sequential synthesis of α,α-disubstituted ketones via the alkylation of secondary alcohols with primary alcohols is reported. Notably, the present approach provides a new method for the facile synthesis of α,α-disubstituted ketones and featured with several characteristics, including a broad substrate scope, using easy-to-handle alcohols as starting materials, and performing the reactions under aerobic conditions. Moreover, the selective one-pot formation of β,β-disubstituted alcohols was achieved by the addition of an external hydrogen source to the reaction mixture.