Inflammatory markers C-reactive protein and PLR in relation to HCC characteristics
Makaleler > Tam Makale · 2018
Yazarlar: Aslı SUNER KARAKÜLAH, BRIAN I CARR, HİKMET AKKIZ, OĞUZ ÜSKÜDAR, SEDEF KURAN, yaman TOKAT, SALİH TOKMAK, HÜSEYİN TUĞSAN BALLI, ABDULLAH ÜLKÜ, ATILGAN TOLGA AKÇAM, ANIL DELIK, BURCU ARSLAN, FİGEN DORAN, KENDAL YALÇIN, NAZIM EKİNCİ, SEZAİ YILMAZ, AYŞEGÜL ÖZAKYOL, MEHMET YÜCESOY, HALİL İBRAHİM BAHÇECİ, KAMİL YALÇIN POLAT, HALİS ŞİMŞEK, NECATİ ÖRMECİ, ABDULLAH SONSUZ, MEHMET DEMİR, Murat KILIÇ, AHMET UYGUN, ALİ DEMİR, ERGİN ALTINTAŞ, GÖKHAN KARAKÜLAH, TUNCER TEMEL, AHMET BEKTAŞ
Journal of Translational Science, Diğer Kurumların Hakemli Dergileri, Uluslararası, Scopus, 2018, cilt 5, ss 1-6
DOI: 10.15761/jts.1000260
Özet
INTRODUCTION: Several markers of systemic inflammation, including blood C-reactive protein, platelet lymphocyte ratio (PLR) and neutrophil lymphocyte ratio (NLR) have been identified as independent prognosticators for hepatocellular carcinoma (HCC). METHODS: To attempt to understand the significance of these markers, they were examined in relation to 4 tumour parameters, namely maximum tumour diameter (MTD), tumour multifocality, portal vein thrombosis (PVT) and blood alpha-fetoprotein (AFP) levels. RESULTS: Using linear and logistic regression models, we found that C-reactive protein and PLR on single variables, were statistically significantly related to the tumour parameters. In a logistic regression final model, CRP was significantly related to MTD, AFP and PVT, and the Glasgow Index significantly related to MTD and AFP. Results of the area under the receiver operating characteristic curves (ROC), showed that the areas for PLR and CRP were statistically significant for high versus low MTD and for presence versus absence of PVT. CRP alone was significant for high versus low AFP. CONCLUSIONS: These analyses suggest that the prognostic usefulness of the inflammatory markers PLR and CRP (but not NLR) may be due to their reflection of parameter values for tumour growth and invasiveness.