Osmotic Release Oral System Methylphenidate is More Effective Than Immediate Release Methylphenidate: A Retrospective Chart Review in Turkish Children with Attention Deficit Hyperactivity Disorder
Makaleler > Tam Makale · 2014
Yazarlar: Ulku Akyol ARDIC, Eyüp Sabri ERCAN, Elif ULU, DENİZ YÜCE, Burge Kabukcu Basay
Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2014, cilt 24, ss 342-349
DOI: 10.5455/bcp.20141009112739
Özet
Objective: The aim of this study was to evaluate the efficacy and safety of osmotic release oral system methylphenidate (OROS-MPH) compared with immediate release methylphenidate (IR-MPH) in Turkish children with attention deficit hyperactivity disorder (ADHD).Method: The medical records of primary school-aged children, who were first-time referrals to the outpatient clinic, were reviewed; 67 children receiving OROS-MPH and 47 children receiving IR-MPH were recruited for the study. A total of 114 children receiving treatment for ADHD were evaluated over 8 weeks.Results: The total Turgay DSM-IV Based Child and Adolescent Behavior Disorders Screening and Rating Scale scores from both the parent and teacher forms decreased significantly in both groups over 8 weeks (p<0.001). OROS-MPH was found to be superior to IR-MPH when comparing baseline-to-8th-week- mean inattention score changes on both the teacher (p=0.007) and parent (p=0.015) forms. OROS-MPH and IR-MPH were both well tolerated, with similar side- effect profiles.Conclusion: OROS-MPH was found to be effective and safe in the treatment of ADHD symptoms in Turkish children.