The clinical features, treatment and prognosis of neutropenic fever and Coronavirus disease 2019 results of the multicentre teos study
Makaleler > Tam Makale · 2024
Yazarlar: Dilsah Baskol Elik, Safak Kaya, Sevil Alkan, Tuna Demirdal, Alper Sener, Selcuk Kaya, Ozlem Guzel Tunccan, Bircan Kayaaslan, Rahmet Guner, Fatma Eser, Hasip Kahraman, Serhat Birengel, Elif Mukime Saricaoglu, Esma Eroglu, Fatma Colkesen, Erman Ozturk, Hande Berk Cam, Cigdem Mermutluoglu, Safak Ozer Balin, Guelden Sincan, Nilguen Altin, Uluhan Sili, Bedia Mutay Suntur, Tugba Arslan Gulen, Burak Deveci, Rabin Saba, Saban Incecik, Gulden Eser Karlidag, Elif Hakko, Damla Akdag, Huseyin Aytac Erdem, Hilal Sipahi, Candan Cicek, Mehmet Sezai Tasbakan, Meltem Tasbakan, Husnu Pullukcu, Tansu Yamazhan, Bilgin Arda, Sercan Ulusoy, Oğuz Reşat SİPAHİ
SCIENTIFIC REPORTS, SCI İndekslerine Giren Dergi, Uluslararası, Wos, 2024, cilt 14, ss 5218-5218
DOI: 10.1038/s41598-024-55886-w
Özet
This multicentre (22 centres in Turkey) retrospective cohort study aimed to assess the clinical outcomes of patients with neutropenic fever and SARS-CoV-2 positivity. Study period was 15 March 2020-15 August 2021. A total of 170 cases (58 female, aged 59 +/- 15.5 years) that fulfilled the inclusion criteria were included in the study. One-month mortality rate (OMM) was 44.8%. The logistic regression analysis showed the following significant variables for the mentioned dependent variables: (i) achieving PCR negativity: receiving a maximum of 5 days of favipiravir (p = 0.005, OR 5.166, 95% CI 1.639-16.280); (ii) need for ICU: receiving glycopeptide therapy at any time during the COVID-19/FEN episode (p = 0.001, OR 6.566, 95% CI 2.137-20.172), the need for mechanical ventilation (p < 0.001, OR 62.042, 95% CI 9.528-404.011); (iii) need for mechanical ventilation: failure to recover from neutropenia (p < 0.001, OR 17.869, 95% CI 3.592-88.907), receiving tocilizumab therapy (p = 0.028, OR 32.227, 95% CI 1.469-707.053), septic shock (p = 0.001, OR 15.4 96% CI 3.164-75.897), and the need for ICU (p < 0.001, OR 91.818, 95% CI 15.360-548.873), (iv) OMM: [mechanical ventilation (p = 0.001, OR 19.041, 95% CI 3.229-112.286) and septic shock (p = 0.010, OR 5.589,95% CI 1.509-20.700)]. Although it includes a relatively limited number of patients, our findings suggest that COVID-19 and FEN are associated with significant mortality and morbidity.