Staphylococcus aureus as a signature species of skin microbiome in actinic keratosis and squamous cell carcinoma: A narrative review
Makaleler > Derleme · 2025
Yazarlar: Nilay DUMAN, GÖKTÜRK ORALOĞLU, Ece Deniz, Ayşe CANER
Dermatologica Sinica, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2025, cilt 43, ss 100-106
Özet
Abstract Cutaneous squamous cell carcinoma (cSCC) is a common type of skin cancer and the second most common type of nonmelanoma skin cancer. Actinic keratosis (AK) is a premalignant lesion that can progress to cSCC over time. AK and cSCC are associated with microbial dysbiosis and an increased abundance of the bacterium Staphylococcus aureus . Although AK and cSCC are highly colonized with S . aureus , a bacterium of the skin microbiota, it is not yet known whether this bacterium is associated with cancer development. Here, we analyze the studies on the relationship between S . aureus and keratinocytic skin neoplasia, evaluating the contribution of S . aureus to the development and prognosis of cSCC and AK lesions. The overabundance of S . aureus and the compounds secreted by this bacterium can induce cancer-promoting changes in skin cells. The presence of high amounts of certain S . aureus strains in premalignant skin lesions may constitute a protumorigenic stimulus by inducing oxidative stress and DNA damage and downregulating DNA repair mechanisms. S . aureus associated with AK and cSCC can trigger keratinocytes to produce inflammatory cytokines typically upregulated in cSCC. These circumstances also suggest a potential specific involvement of S . aureus in the progression from AK to cSCC.