Effects of Aerosolized Adenosine 5′-Triphosphate in Smokers and Patients With COPD
Articles > Article · 2015
Authors: Özen KAÇMAZ BAŞOĞLU, Peter J. Barnes, Sergei A. Kharitonov, Amir Pelleg
Chest, Journal Indexed in SCI Expanded, International, WoS, 2015, vol 148, pp 430-435
Summary
BACKGROUND: Extracellular adenosine 5'-triphosphate (ATP) stimulates vagal C and A delta fibers in the lung, resulting in pronounced bronchoconstriction and cough mediated by P2X2/3 receptors located on vagal sensory nerve terminals. We investigated the effects of nebulized ATP on cough and symptoms in control subjects, healthy smokers, and patients with COPD and compared these responses to the effects of inhaled adenosine, the metabolite of ATP.