Effects of Aerosolized Adenosine 5′-Triphosphate in Smokers and Patients With COPD
Makaleler > Tam Makale · 2015
Yazarlar: Özen KAÇMAZ BAŞOĞLU, Peter J. Barnes, Sergei A. Kharitonov, Amir Pelleg
Chest, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2015, cilt 148, ss 430-435
Özet
BACKGROUND: Extracellular adenosine 5'-triphosphate (ATP) stimulates vagal C and A delta fibers in the lung, resulting in pronounced bronchoconstriction and cough mediated by P2X2/3 receptors located on vagal sensory nerve terminals. We investigated the effects of nebulized ATP on cough and symptoms in control subjects, healthy smokers, and patients with COPD and compared these responses to the effects of inhaled adenosine, the metabolite of ATP.