Association of MMP-2 Variant with Atrial Fibrillation in Elderly Patients: A Comparative Analysis Involving GJA1 and IL-6R Variants.
Makaleler > Tam Makale · 2025
Yazarlar: Akile Tuncal, Hikmet Hakan AYDIN, ELİF KARADADAŞ, Levent Hurkan Can, Emre DEMİR, Handan Ak
Annals of clinical and laboratory science, Uluslararası, 2025, cilt 55, ss 385-392
Özet
OBJECTIVE: Atrial fibrillation (AF) is a common arrhythmia caused by genetic modifications affecting biological processes such as cell communication, inflammation, and ion channels. Changes that occur over time happen gradually. By understanding the functional significance of these variations, we have analyzed single nucleotide polymorphisms (SNPs) in matrix metalloproteinase 2 (MMP-2), connexin 43 (GJA1/CX43), and interleukin 6 receptor (IL-6R) in patients aged 65 or older who have been diagnosed with atrial fibrillation. This analysis is grounded in the biological processes that are related to AF. METHODS: gene. RESULTS: =0.02). CONCLUSION: genetic variations.