In vitro and in vivo evaluation of hydroxypropylmethyl cellulose phthalate capsules
Makaleler > Tam Makale · 2011
Yazarlar: Emel Öykü ÇETİN UYANIKGİL, M. Asikoglu, Evren ATLIHAN GÜNDOĞDU, O. Orumlu, L. Kirilmaz
International Journal of Drug Delivery, Uluslararası, Scopus, 2011, cilt 1, ss 279-285
Özet
The aim of this study was to develop a novel HPMCP capsule. The HPMCP capsule containing 99mTc-DTPA and lactose was evaluated in in vitro and in vivo studies. First of all, the HPMCP capsules were prepared and characterized with lenght and diameter size, brittleness facility, moisture content and microbiological test. In vitro resistance and solubility studies of prepared capsules were tested at pH 1.2 and pH 7.4 buffers. The radiolabeled HPMCP capsules were administrated to fasted volunteers. The disintegration times and positions of capsules were recorded by using gamma scintigraphy. In vitro studies showed that HPMCP capsules were gastro resistant for 2 h at pH 1.2 and dissolved at pH 7.4 in 20-25 minutes. The radiolabeled capsules did not disintegrate in stomach whereas disintegrated in intestines. In conclusion, it was found that, the prepared HPMCP capsules can be an alternative to the hard gelatine capsules and used for intestinal targeting.