PLGA encapsulation effect on Bioquin-HMPAO: radiolabeling and in vitro behaviour on brain and lung cancer cells
Articles > Article · 2016
Authors: Ayfer YURT KILÇAR, Fazilet Zümrüt BİBER MÜFTÜLER, Emin İlker MEDİNE, Volkan TEKİN
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, Journal Indexed in SCI Expanded, International, 2016, vol 310, pp 155-164
DOI: 10.1007/s10967-016-4746-0
Summary
Bioquin-HMPAO (BH) was previously investigated as a novel brain imaging agent by in vivo biodistribution studies. Present studies are carried out to explore radiolabeling and in vitro behaviour evaluation of poly (lactic-co-glycolic acid) (PLGA) encapsulated BH nanocapsules (BH-PLGA NCs). BH-PLGA NCs were characterized utilizing dynamic light scattering and scanning electron microscope. Encapsulation effect on radiolabeling with Tc-99m was examined by stability and lipophilicity studies and effect on in vitro behaviour of Tc-99m-BH was evaluated by incorporation studies on DAOY, U87-MG and A549 cells. It is observed that PLGA encapsulation has a positive and reinforcement effect.