Angiotensin-converting enzyme (ACE), angiotensinogen (AGT), and angiotensin II type 1 receptor (AT1R) gene polymorphisms in generalized aggressive periodontitis
Articles > Article · 2009
Authors: Ali GÜRKAN, Gülnur EMİNGİL, Buket Han SAYGAN, FATMA GÜL ATİLLA, Timur KÖSE, Haluk BAYLAS, Afig BERDELİ
Archives of Oral Biology, Journal Indexed in SCI Expanded, International, WoS, 2009, vol 54, pp 337-344
DOI: 10.1016/j.archoralbio.2008.12.005
Summary
Aim: Host response to periodontopathic microorganisms can be modulated by genetic factors. Accumulated evidence highlighted the role of renin-angiotensin system (RAS) in inflammatory response thus potential implication of this molecular system in the pathogenesis of periodontitis can be suggested. The present study investigated common genetic variants of molecules within the RAS family namely angiotensin-converting enzyme (ACE), angiotensinogen (AGT) and angiotensin 11 type 1 receptor (AT1R) in relation to generalized aggressive periodontitis (G-AgP).