Exploring Beta Blockers’ Efficacy in Sepsis-Induced Acute Lung Injury and HMGB1-sRAGE Interaction
Makaleler > Tam Makale · 2023
Yazarlar: REZAN KARAALİ, EJDER SAYLAV BORA, Hüseyin Acar, Yiğit UYANIKGİL, İBRAHİM HALİL SEVER, MÜMİN ALPER ERDOĞAN, OYTUN ERBAŞ
International Journal of Pharmacology, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2023, cilt 19, ss 296-304
Özet
Background and Objective: Beta-blockers improve cardiac function and prevent catecholamine-mediated hypermetabolism in critically ill patients.This study investigated the role of beta blockers in reducing inflammation in a sepsis model and their influence on acute lung injury (ALI).The study aimed to understand beta blockers' potential role in mitigating ALI risk in sepsis patients.Materials and Methods: Fifty Wistar albino rats were divided into five groups.The first group was the control and the remaining four had feces-induced peritonitis (FIP) to mimic sepsis.The second group was the FIP group, while the third, fourth and fifth groups received different intraperitoneal doses of beta-blockers: 10 mg/kg/day of propranolol, 2 mg/kg/day of metoprolol and 5 mg/kg/day of carvedilol.Results: Beta-blocker administration in FIP rats significantly decreased inflammatory biomarkers, including Tumor Necrosis Factor-alpha (TNF-"), lactic acid, Interleukin-6 (IL-6), malondialdehyde (MDA), high mobility group box 1 (HMGB1) and Interleukin-1 beta (IL-1$), compared to the FIP+Saline group.The FIP+beta blockers group exhibited elevated Soluble Receptors for Advanced Glycation End product (s-RAGE) levels compared to the FIP+saline group.Carvedilol, metoprolol and propranolol showed distinct mechanisms, resulting in biochemical improvements in sepsis and curative effects observed in computed tomography and histology.These findings suggested that beta-blockers may effectively prevent ALI side effects in sepsis treatments.Conclusion: Commencing beta-blocker treatment alongside standard sepsis therapy could potentially protect against adverse effects like ALI.It is recommended to consider adding beta-blockers to standard sepsis treatment regimens.