Positional obstructive sleep apnea in the European Sleep Apnoea Database (ESADA) study
Bildiriler > Özet Bildiri · 2018
Yazarlar: Izolde Bouloukaki, Athanasia Pataka, Paschalis Steiropoulos, Ludger Grote, Marisa Bonsignore, Jan Hedner, Oreste Marrone, Özen KAÇMAZ BAŞOĞLU, Johan Verbraecken, Carolina Lombardi, Gianfranco Parati, Zoran Dogas, Sophia Schiza
Sleep and control of breathing, Fransa, Uluslararası, Sözlü Sunum, Özet Bildiri, 2018-2018, Wos, cilt 52, ss PA4335-PA4335
DOI: 10.1183/13993003.congress-2018.pa4335
Özet
Background: Positional obstructive sleep apnoea (pOSA) is an important sleep apnea phenotype. However, data on the risk factors and health impact of POSA are limited. Aims and Objectives: To estimate the prevalence and risk factors for pOSA in the European Sleep Apnoea Database (ESADA) cohort and to analyze clinical and polysomnographic characteristics associated with POSA. Methods: A multi-centric subsample of 1084 patients from the ESADA cohort was evaluated. Positional OSA was defined as an overall apnea-hypopnea index (AHI) ≥5, supine AHI to non-supine AHI ratio of ≥2 and an AHI that normalizes (AHI < 5) in the non-supine posture. We compared clinical and polysomnographic variables between patients with and without pOSA and investigated predictive factors for pOSA using binary logistic regression analysis. Results: 27% of patients fulfilled the pOSA criteria. These patients were significantly younger (47 vs 50, p<0.001), leaner (BMI 28 vs 30, p<0.001, neck circumference 39 vs 41, p<0.001). Comorbid hypertension (25 vs 34%, p=0.004), Type 2 diabetes (5 vs 11% p=0.005) and hyperlipidemia (36 vs 48% p<0.001) were less prevalent in pOSA compared to non-pOSA patients. AHI and ODI, were lower in pOSA (10 vs 24 and 5 vs 9, all p<0.001). Sleep architecture was also better preserved in pOSA patients indicated by lower %N1 and higher %N3 (p<0.001). 74% of pOSA patients fulfilled the criteria of mild OSA (overnight AHI 5-<15) compared to 29% in the non-pOSA group. Independent predictors of pOSA were young age and low AHI. Conclusions: pOSA prevalence in our cohort was found lower than previously reported. The pOSA phenotype reflects the mild OSA disease spectrum with a low degree of comorbidities.