Tobacco‐induced suppression of the vascular response to dental plaque
Articles > Article · 2018
Authors: Nurcan Gülsüm BUDUNELİ, D. A. Scott
Molecular Oral Microbiology, Journal Indexed in SCI Expanded, International, WoS, 2018, vol 33, pp 271-282
DOI: 10.1111/omi.12228
Summary
Cigarette smoking presents oral health professionals with a clinical and research conundrum: reduced periodontal vascular responsiveness to the oral biofilm accompanied by increased susceptibility to destructive periodontal diseases. This presents a significant problem, hampering diagnosis and complicating treatment planning. The aim of this review is to summarize contemporary hypotheses that help to explain mechanistically the phenomenon of a suppressed bleeding response to dysbiotic plaque in the periodontia of smokers. The influence of smoke exposure on angiogenesis, innate cell function, the production of inflammatory mediators including cytokines and proteases, tobacco-bacteria interactions, and potential genetic predisposition are discussed.