Toxoplasma gondii RH Ankara: Production of evolving tachyzoites using a novel cell culture method
Makaleler > Tam Makale · 2011
Yazarlar: Aysu DEĞİRMENCİ DÖŞKAYA, Mert DÖŞKAYA, Ayşe CANER, Candan ÇİÇEK, Metin KORKMAZ, Adnan Yüksel GÜRÜZ, AHMET ÜNER
Experimental Parasitology, SCI Expanded İndekslerine Giren Dergi, Uluslararası, Wos, 2011, cilt 128, ss 1-8
DOI: 10.1016/j.exppara.2011.01.019
Özet
Toxoplasma gondii is one of the most researched parasite due to its easy growth both in vitro and in vivo. Tachyzoites, derived from mouse or rat peritoneum encounters ethical and economical problems when used for research or diagnostic purposes. Currently, research has focused on determining the most suitable cell culture environment to reach highest amount of viable tachyzoites with least host cell contamination. However, gene expression changes that take place throughout the adaptation of evolving T. gondii strains to continuous cell cultures appear as a problem.