Epstein-Barr virus-related lymphoproliferative disorders in T-cell repleted haploidentical transplantation with post-transplant cyclophosphamide
Articles > Article · 2021
Authors: Vedat Uygun, Nazan ÖZSAN, Hayriye Daloglu, Seda Ozturkmen, Koray Yalcin, Gulsun Karasu, Akif Yesilipek
International Journal of Hematology, Journal Indexed in SCI Expanded, International, WoS, 2021, vol 115, pp 600-604
DOI: 10.1007/s12185-021-03267-8
Summary
EBV-associated lymphoproliferative disorders (LPDs) are common in hematopoietic stem cell transplantation (HSCT) with T-cell-depleted grafts, but are extremely rare in HSCT patients with T-cell-replete grafts with post-transplant cyclophosphamide (PTCy). Here we present the cases of two pediatric patients who developed EBV-related LPD after T-cell-replete haplo-HSCT with PTCy. One of these is the first reported case of EBV-positive mucocutaneous ulcer (EBVMCU) developing after PTCy. EBV-related diseases are rare in T-cell-replete haplo-HSCT patients with PTCy. However, in patients with risk factors, it is reasonable to screen for EBV viremia for LPD.