The Follow-Up of Biomarkers Better Predicts the Poor Outcome in COVID-19 Patients
Articles > Article · 2020
Authors: Ozen K. Basoglu, MUSTAFA HİKMET ÖZHAN, Pervin KORKMAZ, Güneş AK, Mehmet Sezai TAŞBAKAN, Abdullah SAYINER
ANNALS OF CLINICAL AND LABORATORY SCIENCE, Journal Indexed in SCI Expanded, International, 2020, vol 50, pp 848-851
Summary
Objective. To investigate the course of biomarkers on admission and follow-up in order to identify early predictors for poor outcome in COVID-19 patients. Methods. In this study, 132 COVID-19 patients were classified as good outcome (n=62) and poor outcome (n=70) groups. Laboratory parameters were evaluated on admission and within 5-7 days after hospitalization. Results. Baseline levels of neutrophil-lymphocyte ratio, CRP, procalcitonin, ferritin, D-dimer and LDH were higher (p<0.01); lymphocyte count was lower in the poor outcome patients. During follow-up there was a larger decrease in lymphocyte count and more prominent increases in other biomarkers (p<0.001). In ROC analysis, the AUCs strongly indicated the poor outcome on days 5-7 of the hospitalization. Conclusions. This study suggests that the follow-up measurements of the biomarkers better predict the poor outcome in COVID-19 pneumonia.