P5309The relationship between lipoprotein a and aortic calcification in familial hypercholesterolemia
Makaleler > Tam Makale · 2017
Yazarlar: M. Kayikcioglu, R. Huseynov, Selen BAYRAKTAROĞLU, L.H. Can, S. Payzin
European Heart Journal, Uluslararası, Wos, 2017, cilt 38
DOI: 10.1093/eurheartj/ehx493.p5309
Özet
The lipoprotein a levels have been documented to be associated with aortic valve calcification (AVC) which is an active atherosclerotic process. In this study we evaluated the association between AVC and Lipoprotein a [Lp(a)] in patients with familial hypercholesterolemia (FH). Also, the association between Lp(a) and arcus aorta calcification (AAC), coroner artery calcium score (CACS) and aortic elastic features. Methods: The study population consisted of 117 patients (55±13 years of age) who were followed at a University Hospital lipid outpatient clinic for FH and had been evaluated for CACS. CACS imaging was re-evaluated for AVC and AAC by cardiac computed tomography and aortic arch elasticity was evaluated with transthoracic echocardiography. Aortic elastic properties were measured by echocardiography included elastic modulus, aortic stiffnes index, and aortic distensibility. Patients were divided into two groups as Lp(a) levels less than 30mg/dl and higher and equal to 30mg/dl. Results: There was a moderate correlation between AVC and serum Lp(a) (p<0.001 rho=0.43). AAC and CACS had a low correlation with serum Lp(a) levels (p:0,045 rho:0.192 and p:0.01 rho:0.24, respectively). Also we have found that high Lp(a) levels were associated with deteriorated elastic features of arcus aorta. When divided subjects according to Lp(a) levels (less than 30mg/dl and higher and equal to 30mg/dl), patients with high serum Lp(a) had higher AVC, AAC and CACS, more deterioration of the elastic features, which was statistically significant.